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About ARALAST NP Therapy

ARALAST NP ARALAST NP

Therapy Options for Alpha-1

People with lung disease related to AAT deficiency have a number of therapy options available. Talk to your healthcare provider about the options that are best for you.

Protect Your Lungs

It is very important for Alpha-1 patients to do everything possible to slow or prevent lung damage. Some protective measures your doctor may recommend include:

  • Stop smoking – the first and most essential protective step
  • Avoid all forms of tobacco smoke, including second-hand smoke from other smokers
  • Avoid occupational and environmental pollutants, including dust and pollen
  • Avoid wood-burning stoves
  • Avoid fumes from household cleaning products
  • Avoid paint and/or other toxic agents

Stay as Healthy as Possible

It is also important for Alpha-1 patients to maintain overall good health. Your doctor may recommend that you:

  • Participate in a pulmonary rehabilitation plan
  • Follow a good nutrition and exercise program
  • Stay current with immunizations for flu and pneumonia
  • Reduce alcohol consumption
  • Keep regular physician appointments, take prescribed medications, and follow professional advice
  • Avoid exposure to people who are sick
  • Develop a stress-management program

“Pulmonary rehabilitation” combines many of the lifestyle and lung-protection recommendations into a structured program. Ask your doctor whether a pulmonary rehabilitation program could help you control symptoms and achieve your highest level of activity.

Consider Medications

For Treatment of Respiratory Symptoms

Some medications are available to help people who have breathing problems associated with asthma, emphysema, and COPD:

  • Bronchodilators (to reduce airway constriction)
  • Corticosteroids (to reduce inflammation)
  • Supplemental oxygen

For Treatment of Infections

To help prevent further lung damage, your doctor may also want to treat any upper respiratory infections with antibiotics as soon as possible. Be sure to contact your doctor at the first sign of an infection.

For Treatment of Mental Health Symptoms

Sometimes people with breathing difficulties experience depression, panic, or anxiety. There are therapies and/or medications that your doctor can prescribe to treat these conditions. There are also medications and devices available to help manage sleep disorders.

Augmentation Therapy

Augmentation therapy with an alpha1-proteinase inhibitor (A1-PI) such as ARALAST NP therapy may be appropriate for you if you have alpha-1 antitrypsin (AAT) deficiency with clinically evident emphysema. Augmentation therapy can help increase the low levels of AAT in the blood and in the lungs. A1-PI augmentation therapy is not a cure for AAT deficiency. It cannot repair damage that has already occurred in your lungs. However, augmentation therapy can raise the level of alpha-1 in your blood above the protective threshold recommended by the ATS/ERS standards.1,2,3

Augmentation therapy is administered intravenously (in a vein) once a week. You can receive this therapy in your home or workplace.

Surgical Options

Some Alpha-1 patients with advanced lung disease may be candidates for lung transplantation. This option may be considered if there is advanced lung disease that has not responded to more conservative therapy.

ARALAST NP [Alpha1-Proteinase Inhibitor (Human)]

ARALAST NP is indicated for chronic augmentation therapy in patients having congenital deficiency of A1-PI with clinically evident emphysema. ARALAST NP is not indicated as therapy for lung disease patients in whom congenital A1-PI deficiency has not been established.

The effect of augmentation therapy with ARALAST NP on pulmonary exacerbations and on the progression of emphysema in alpha1-antitrypsin deficiency has not been demonstrated in randomized, controlled clinical trials.

Please review the Important Risk Information and the Full Prescribing Information

Please review the Important Risk Information and the Full Prescribing Information

References

  1. American Thoracic Society/European Respiratory Society Statement: Standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2003;168:818-900.
  2. ARALAST NP [Alpha1–Proteinase Inhibitor (Human)] Prescribing Information, Baxter International Inc., Westlake Village, CA; April 2010.
  3. Stolk, J. Alpha-1-antitrypsin augmentation treatment: does one size fit all? Thorax.2006;61:1034.